2-Amino-6-bromopyridine → 6-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-ylamine

HRID 1401867Notes

Reaction equation

HRID 1401867 reaction equation
Br[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB([C:17]2[CH:26]=[CH:25][C:24]3[C:23]([CH3:28])([CH3:27])[CH2:22][CH2:21][C:20]([CH3:30])([CH3:29])[C:19]=3[CH:18]=2)O1>>[CH3:27][C:23]1([CH3:28])[CH2:22][CH2:21][C:20]([CH3:30])([CH3:29])[C:19]2[CH:18]=[C:17]([C:2]3[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=3)[CH:26]=[CH:25][C:24]1=2

Participants

3

Reactant 2

HCID 3008092-Amino-6-bromopyridineHCID 112439294,4,5,5-Tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane

Product 1

HCID 673240416-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)pyridin-2-ylamine

Procedure

The preparation is carried out as already described starting from 2.30 g (13.0 mmol) of 6-bromopyridin-2-ylamine and 5.22 g (13.7 mmol) of 4,4,5,5-tetramethyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,2-dioxaborolane.

Sources & evidence

ORD record
ord-6586621e3a444a9c98cbc4210e888488
Source dataset
uspto-grants-2014_12
Patent number
US08907098B2

Reaction notes

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