反应详情

Acetic anhydride (4 grams) was added to the solution of (R)-2-amino-N-benzyl-3-hydroxypropanamide compound of formula-10 (6 grams) in dichloromethane (60 ml) at 10-15° C. The reaction mixture was stirred for 3 hours and reaction mixture quenched with water. Both the organic and aqueous layers were separated. The organic layer was washed with aqueous sodium bicarbonate solution followed by water. The organic layer was distilled off completely under reduced pressure to get the title compound.

1. customreaction mixture
2. customquenched with water
3. customBoth the organic and aqueous layers were separated
4. washThe organic layer was washed with aqueous sodium bicarbonate solution
5. distillationThe organic layer was distilled off completely under reduced pressure