Lithium Hydroxide → HCID 71238281, compound

Participants

Reaction Steps

To 4-{2-[4-(4-(R)-tert-Butylcyclohex-1-enyl)-phenyl]-2-ethoxylcarbonyl-ethyl}-benzoic acid tert-butyl ester (63 mg, 0.13 mmol) dissolved in a solution of THF (3 mL), MeOH (1 mL) and water (1 mL) was added lithium hydroxide (27 mg, 0.64 mmol). The solution was stirred at rt for 5 hrs then neutralized with 3M KH2PO4 and extracted with ethyl acetate. The organic portion was washed with brine, dried over Na2SO4 and concentrated under vacuum to afford crude material which was used without further purification.

Provenance & Evidence