HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 2,4-Difluorobenzenesulfonyl Chloride | HCID 2734273 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,4-difluoro-N-(thiazol-2-yl)benzenesulfonamide | HCID 25038904 | — |
Reaction Steps
To a slurry of 2-aminothiazole (15.08 g, 0.1506 mol) in methylene chloride (100 mL) and pyridine (24 mL, 0.30 mol) was added dropwise over 20 minutes a solution of 2,4-difluorobenzenesulfonyl chloride (10 mL, 0.07 mol) in 10 mL of methylene chloride. After stirring at room temperature for 48 hours the reaction was concentrated and purified by flash column chromatography eluting with hexane/ethyl acetate. LCMS Rt=1.21 minutes MS m/z 277 [MH]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08907101B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-848ed5642e2944c395380b885b302f03 |
| Source note | uspto-grants-2014_12 |