HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1402050Generated: November 1, 2026
Dimethylformamide dimethyl acetal → (2E)-3-(dimethylamino)-1-[2-hydroxy-5-(trifluoromethyl)phenyl]prop-2-en-1-one
https://huagongshe.com/reaction/1402050
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 1-(2-Hydroxy-5-(trifluoromethyl)phenyl)ethan-1-one | HCID 11769599 | — |
| Product | (2E)-3-(dimethylamino)-1-[2-hydroxy-5-(trifluoromethyl)phenyl]prop-2-en-1-one | HCID 59436605 | — |
Reaction Steps
1-[2-Hydroxy-5-(trifluoromethyl)phenyl]ethanone, (Preparation 860, 7.0 g, 0.0343 mol) was taken in dimethylformamide dimethylacetal (18.2 mL, 0.137 mol) at room temperature and then heated at 110° C. for 30 min. The reaction mixture was concentrated in vacuo and the crude product was crystallised from 2-propanol to give the title compound as bright yellow solid (6.4 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08907101B2 |
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| Source dataset | uspto-grants-2014_12 |
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| ORD ID | ord-d8a6aaf5d2b344b0aa58aee0af9134f9 |
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| Source note | uspto-grants-2014_12 |
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