Hydrochloric Acid → HCID 71542907, compound

Participants

Reaction Steps

To a stirred solution of N-(2,2-diethoxyethyl)-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}1H-pyrrole-3-carboxamide (580 mg, 1.03 mmol) in 10 ml of THF was added 1 ml of 2M HCl. The mixture was heated under nitrogen at 60 C. for 2 hours, cooled to room temperature, and poured into 100 ml of water. Saturated NaHCO3 solution was added until pH=8. The precipitates were filtered, washed with water, and dried in vacuo to give 5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-N-(2-oxoethyl)-1H-pyrrole-3-carboxamide as light brown solid. Yield: 450 mg, 90%.

Provenance & Evidence