Water → HCID 71293523, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of N-(3-aminopropyl)-5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrole-3-carboxamide (85 mg, 0.17 mmol) and N,N-diisopropylethylamine (100 mg, 0.78 mmol) in 10 ml of anhydrous DMF was added methyl bromoacetate (100 mg, 0.65 mmol). The mixture was heated at 55° C. for 30 minutes and poured into 100 ml of water with vigorous stirring. The precipitates were filtered and dried in vacuo to give the crude, which was purified by silica gel chromatography eluting with 3˜5% of MeOH in CHCl3 to afford dimethyl 2,2′-({3-[([5-[4-(2-fluoro-5-{[(2-fluoro-5-methylphenyl)amino]carbonyl}phenoxy)pyridin-2-yl]-1H-pyrrol-3-yl]carbonyl)amino]propyl}imino)diacetate as white solid. Yield: 70 mg, 64%.

Provenance & Evidence