Hydrochloric Acid → HCID 71293489, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of methyl 1-(3-{[(5-{4-[3-fluoro-4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]amino}propyl)pyrrolidine-2-carboxylate (100 mg, 0.16 mmol) in 1 ml of MeOH was added 0.2N NaOH solution (2 ml, 0.4 mmol). The mixture was heated at 50° C. for 16 hours and cooled to room temperature. 1M HCl was added dropwise with vigorous stirring until pH=7. The precipitates were filtered, washed with water and dried in vacuo to give 1-(3-{[(5-{4-[3-fluoro-4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]amino}propyl)pyrrolidine-2-carboxylic acid as white solid. Yield: 72 mg, 73%.

Provenance & Evidence