Water → HCID 71293579, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred suspension of N-(3-aminopropyl)-5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide (200 mg, 0.40 mmol) and N,N-diisopropylethylamine (0.5 ml, 2.8 mmol) in 10 ml of anhydrous THF was added methyl bromoacetate (200 mg, 1.30 mmol). The mixture was heated at 60° C. for 16 hours and poured into 100 ml of water with vigorous stirring. The precipitates were filtered and dried in vacuo to give the crude, which was purified by silica gel chromatography eluting with 5% of MeOH in CHCl3 to afford dimethyl 2,2′-[(3-{[(5-{4-[4-({[(2-fluoro-5-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrol-3-yl)carbonyl]amino}propyl)imino]diacetate as white solid. Yield: 210 mg, 82%.

Provenance & Evidence