3-Amino-1-propanol → HCID 71293502, compound

Participants

Reaction Steps

To a stirred solution of 5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxylic acid (1.00 g, 2.34 mmol) in 20 ml of anhydrous DMF were added HATU (1.07 g, 2.80 mmol) and N,N-diisopropylethylamine (604 mg, 4.68 mmol). The mixture was stirred at room temperature for 10 minutes, followed by addition of 3-amino-1-propanol (263 mg, 3.51 mmol). The mixture was stirred for another 5 minutes and poured into 200 ml of water with vigorous stirring. The precipitates were filtered, washed with water and dried in vacuo to give N-(3-hydroxypropyl)-5-{4-[4-({[(3-methylphenyl)amino]carbonyl}amino)phenoxy]pyridin-2-yl}-1H-pyrrole-3-carboxamide as white solid. Yield: 1.10 g, 97%.

Provenance & Evidence