HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Carbamoyl-5-dipropylcarbamoyl-benzoic acid → N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Carbamoyl-5-dipropylcarbamoyl-benzoic acid | HCID 22394891 | — |
| Reactant | (2R,3S)-3-amino-4-(3,5-difluorophenyl)-1-[(3-methoxybenzyl)amino]-2-butanol Trifluoroacetate | HCID 69869154 | — |
| Product | N-{(1S,2R)-1-benzyl-2-hydroxy-3-[(3-methoxybenzyl)amino]propyl}-5-(hydroxymethyl)-N3,N3-dipropylisophthalamide | HCID 68610888 | — |
Reaction Steps
Following the procedure of CHART P and Example 739 and making non-critical variations but using 3-[(dipropylamino)carbonyl]-5-(hydroxymethyl)benzoic acid (IX) and (2R,3S)-3-amino-1-[(3-methoxybenzyl)amino]-4-phenyl-2-butanol (VIII), the title compound is obtained, HRMS (FAB)=615.3571.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07727997B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d7129d6dce2e450d859df2905d292e8c |
| Source note | uspto-grants-2010_06 |