Benzyl Chloride → Benzyl ursolate

Participants

Reaction Conditions

Reaction Steps

5 g of ursolic acid was dissolved in 300 ml of dimethylformamide, and 63 ml of triethylamine was added thereto. Then, 20 g of benzyl chloride was added thereto, and the whole was stirred at 50° C. for 1 hour and concentrated under reduced pressure, followed by purification by silica gel chromatography (elution solvent; chloroform:methanol=100:0 to 80:20), to thereby obtain benzyl ursolate.

Provenance & Evidence