Bromine → HCID 66611137, compound

HRID 1402672Notes

Reaction equation

HRID 1402672 reaction equation
[CH:1]1([C:4]([N:6]2[CH2:12][CH2:11][CH2:10][C:9](=[O:13])[CH2:8][CH2:7]2)=[O:5])[CH2:3][CH2:2]1.[Br:14]Br>C(O)(=O)C>[Br:14][CH:10]1[CH2:11][CH2:12][N:6]([C:4]([CH:1]2[CH2:2][CH2:3]2)=[O:5])[CH2:7][CH2:8][C:9]1=[O:13]

Participants

4

Reactant 2

HCID 24408BromineHCID 66610707HCID 66610707, compound

Product 1

HCID 66611137HCID 66611137, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 1-Cyclopropanecarbonyl-azepan-4-one (2.7 grams, 14.9 mmol, obtained in above step) in acetic acid (30 mL) was cooled to 10° C. and treated with bromine (0.71 mL, 14.9 mmol) over a period of 15 minutes. The resulting slurry was stirred for 18 hours under nitrogen atmosphere. After completion of reaction, mass was concentrated to dryness to obtain the title compound (3.87 grams).

Workup

  1. customAfter completion of reaction, mass
  2. concentrationwas concentrated to dryness

Sources & evidence

ORD record
ord-a2002e0d64bf4f6cbca0eab473c002fc
Source dataset
uspto-grants-2014_12
Patent number
US08912179B2

Reaction notes

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