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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1402673Generated: October 31, 2026

Thiourea → HCID 86719966, compound

https://huagongshe.com/reaction/1402673

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThioureaHCID 2723790—
ReactantHCID 66611137HCID 66611137—
SolventIsopropanolHCID 3776—
ProductHCID 86719966HCID 8671996611.4%

Reaction Steps

A suspension of 5-Bromo-1-cyclopropanecarbonyl-azepan-4-one (3.87 grams, 14.8 mmol, obtained in above step) and thiourea (1.13 grams, 14.8 mmol) in isopropanol (40 mL) was refluxed for 6 hours. After completion of reaction, reaction mass was concentrated and the residue obtained was purified by flash chromatography (methanol/chloroform, 3/97) to obtain the title compound (0.4 grams).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08912179B2
Source datasetuspto-grants-2014_12
ORD IDord-7f23ba53fe114baf830c0b69103db672
Source noteuspto-grants-2014_12