反应详情

3-phenoxypropionic acid (5.0 g, 30 mmol) was dissolved in MeOH (12 mL) and H2SO4 (18 M, 3 drops) was added. The mixture was place in the microwave reactor (T: 140° C., t: 5 min). The solvent was evaporated, the mixture was partitioned in EtOAc (30 mL) and NaOH (2N, 20 mL). The organic phase was dried over MgSO4, filtered, and evaporated to give methyl 3-phenoxypropanoate (5.0 g, 27.7 mmol, 92.5%).

1. customin the microwave reactor (T: 140° C., t: 5 min)
2. customThe solvent was evaporated
3. customthe mixture was partitioned in EtOAc (30 mL)
4. dry with materialThe organic phase was dried over MgSO4
5. filtrationfiltered
6. customevaporated