Thionyl Chloride → HCID 12873573, compound

HRID 1402696Notes

Reaction equation

HRID 1402696 reaction equation
S(Cl)([Cl:3])=O.O[CH2:6][N:7]1[C:11]([CH3:13])([CH3:12])[C:10](=[O:14])[NH:9][C:8]1=[O:15]>C(Cl)Cl>[Cl:3][CH2:6][N:7]1[C:11]([CH3:13])([CH3:12])[C:10](=[O:14])[NH:9][C:8]1=[O:15]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 670001-(Hydroxymethyl)-5,5-dimethylhydantoin

Product 1

HCID 12873573HCID 12873573, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
25 °C

Procedure

0.69 ml Thionyl chloride was added to a solution of 500 mg 1-Hydroxymethyl-5,5-dimethyl-imidazolidine-2,4-dione in 5 ml DCM at 0° C. for 30 minutes, then left to stir at 25° C. for 16 hours. The mixture was evaporated to dryness and used crude in the synthesis of example 23.

Workup

  1. waitleft
  2. customThe mixture was evaporated to dryness
  3. customin the synthesis of example 23

Sources & evidence

ORD record
ord-609eed20e0a14a0cb47a0ebc68b40883
Source dataset
uspto-grants-2014_12
Patent number
US08912173B2

Reaction notes

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