3-(4-Chlorophenyl) glutarate → 4-(4-chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Participants

Reaction Steps

The suspension of commercial 3-(4-chlorophenyl)glutaric acid (15 g) in acetyl chloride (20 ml) was heated to reflux for 2 h. Then precipitation of the product is completed by addition of petrol ether (50 ml) and cooling to rt. The precipitate is isolated by suction filtration, washed with petrol ether, and dried in vacuo to give 3-(4-chlorophenyl)glutaric anhydride (13.3 g) as colourless crystals.

Provenance & Evidence