HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 66759374, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | O-Phenylenediamine | HCID 7243 | — |
| Reactant | 4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione | HCID 104639 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 66759374 | HCID 66759374 | — |
Reaction Steps
The solution of commercial 1,2-phenylenediamine (1.08 g) and 3-(4-chlorophenyl)glutaric anhydride (2.25 g) in 1,4-dioxane (7 ml) was stirred at rt for 10 min. A voluminous precipitate is formed which is kept at rt for further 50 min. The thick slurry is heated to reflux with methanol, cooled to rt, isolated by suction filtration, and washed with methanol. After drying in vacuo N-(2-aminophenyl)-3-(4-chlorophenyl)glutaramic acid (2.1 g) is obtained as off-white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912186B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-d4dd595954804945991d5798438125cd |
| Source note | uspto-grants-2014_12 |