Hydrochloric Acid → HCID 45380877, compound

Participants

Reaction Conditions

Reaction Steps

The solution of ethyl 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (200 mg) in a mixture of acetic acid (1 ml) and conc. HCl (0.25 ml) was heated at 100° C. for 1 h. Then toluene (30 ml) was added and all volatiles were removed by distillation. Distillation was repeated with further toluene (30 ml). The oily residue is treated with diethyl ether to induce crystallisation, triturated with acetone, and dried in vacuo to leave 4-(2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid•HCl (208 mg) as light red solid.

Provenance & Evidence