4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione → HCID 45380883, compound

HRID 1402779Notes

Reaction equation

HRID 1402779 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([NH2:9])[CH:3]=1.[Cl:10][C:11]1[CH:16]=[CH:15][C:14]([CH:17]2[CH2:23][C:22](=O)[O:21][C:19](=[O:20])[CH2:18]2)=[CH:13][CH:12]=1>>[Cl:10][C:11]1[CH:12]=[CH:13][C:14]([CH:17]([CH2:23][C:22]2[NH:9][C:4]3[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=3[N:8]=2)[CH2:18][C:19]([OH:21])=[O:20])=[CH:15][CH:16]=1.[ClH:10]

Participants

3

Reactant 2

HCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dioneHCID 1645844-Fluorobenzene-1,2-diamine

Product 1

HCID 45380883HCID 45380883, compound

Procedure

By a procedure similar to that of 1.4, starting from commercial 4-fluoro-1,2-phenylenediamine and 3-(4-chlorophenyl)glutaric anhydride, 3-(4-chlorophenyl)-4-(5-fluoro-2-benzimidazolyl)butanoic acid•HCl was obtained as colourless solid.

Sources & evidence

ORD record
ord-97daf22cb2b747c7bc72af55518e030b
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

Loading…