4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione → HCID 178479757, compound

HRID 1402782Notes

Reaction equation

HRID 1402782 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]2[CH2:24][C:23](=O)[O:22][C:20](=[O:21])[CH2:19]2)=[CH:14][CH:13]=1>>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]2[N:9]=[C:23]([CH2:24][CH:18]([C:15]3[CH:14]=[CH:13][C:12]([Cl:11])=[CH:17][CH:16]=3)[CH2:19][C:20]([OH:22])=[O:21])[NH:10][C:4]=2[CH:3]=1.[ClH:1]

Participants

3

Reactant 2

HCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dioneHCID 7357734-Chloro-5-fluoro-1,2-phenylenediamine

Product 1

HCID 178479757HCID 178479757, compound

Procedure

By a procedure similar to that of example 1.4, starting from commercial 4-chloro-5-fluoro-1,2-phenylenediamine and 3-(4-chlorophenyl)glutaric anhydride, 4-(5-chloro-6-fluoro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid•HCl was obtained as light greyish solid.

Sources & evidence

ORD record
ord-a122e15fe31c4927930029e57a5312cd
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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