4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione → HCID 45380980, compound

HRID 1402783Notes

Reaction equation

HRID 1402783 reaction equation
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([NH2:10])[CH:4]=1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]2[CH2:26][C:25](=O)[O:24][C:22](=[O:23])[CH2:21]2)=[CH:16][CH:15]=1>>[Cl:13][C:14]1[CH:15]=[CH:16][C:17]([CH:20]([CH2:26][C:25]2[NH:10][C:5]3[CH:4]=[C:3]([C:2]([F:11])([F:12])[F:1])[CH:8]=[CH:7][C:6]=3[N:9]=2)[CH2:21][C:22]([OH:24])=[O:23])=[CH:18][CH:19]=1.[ClH:13]

Participants

3

Reactant 2

HCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dioneHCID 5208224-Trifluoromethyl-1,2-phenylenediamine

Product 1

HCID 45380980HCID 45380980, compound

Procedure

By a procedure similar to that of example 1.4, starting from commercial 4-trifluoromethyl-1,2-phenylenediamine and 3-(4-chlorophenyl)glutaric anhydride, 3-(4-chlorophenyl)-4-(5-trifluoromethyl-2-benzimidazolyl)butanoic acid•HCl was obtained as colourless solid.

Sources & evidence

ORD record
ord-759163c837c04d05b0540e021d9eea1c
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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