4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione → HCID 45380982, compound

HRID 1402784Notes

Reaction equation

HRID 1402784 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([NH2:9])=[C:4]([NH2:10])[CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]2[CH2:24][C:23](=O)[O:22][C:20](=[O:21])[CH2:19]2)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([CH:18]([CH2:24][C:23]2[NH:10][C:4]3[CH:3]=[C:2]([F:1])[C:7]([F:8])=[CH:6][C:5]=3[N:9]=2)[CH2:19][C:20]([OH:22])=[O:21])=[CH:16][CH:17]=1.[ClH:11]

Participants

3

Reactant 2

HCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dioneHCID 27367551,2-Diamino-4,5-difluorobenzene

Product 1

HCID 45380982HCID 45380982, compound

Procedure

By a procedure similar to that of example 1.4, starting from commercial 4,5-difluoro-1,2-phenylenediamine and 3-(4-chlorophenyl)glutaric anhydride, 3-(4-chlorophenyl)-4-(5,6-difluoro-2-benzimidazolyl)butanoic acid•HCl was obtained as light greyish solid.

Sources & evidence

ORD record
ord-a3d321f451b544fab34cb0017bde9ce8
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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