Nitric Acid → HCID 66759560, compound

Participants

Reaction Conditions

Reaction Steps

N-(4-Phenoxyphenyl)-3-(4-chlorophenyl)glutaramic acid (1.41 g) was dissolved in acetic acid (3 ml) with heating. The solution was allowed to cool to 30° C. With vigorous stirring fuming nitric acid (0.7 ml) was rapidly added in portions. The resulting hot, orange coloured solution was stirred at rt for 0.5 h. With ice cooling water (15 ml) was added slowly. From the gummy, yellow precipitate the aqueous layer is removed by decantation. Crystallisation is induced by heating with methanol (4 ml). After cooling to rt the precipitate is isolated by filtration, washed with methanol, and dried in vacuo to yield bright yellow crystals (1.21 g) of N-(2-nitro-4-phenoxyphenyl)-3-(4-chlorophenyl)glutaramic acid.

Provenance & Evidence