Hydrochloric Acid → HCID 66758918, compound

Participants

Reaction Steps

To a solution of 3-(4-chlorophenyl)-N-(3-nitro-[1,1′-biphenyl]-4-yl)glutaramic acid (0.52 g) in acetic acid (3 ml) iron powder (0.34 g) was added. The mixture was stirred vigorously at under reflux for 0.5 h. Then conc. HCl (2 ml) was added with caution. The resulting solution was stirred at reflux temperature for further 2 h. All volatiles were removed at the water aspirator and the residue was dissolved in acetic acid/conc. HCl 2:1 (3 ml). Water (3 ml) was added at reflux temperature and the mixture was left standing at rt overnight. The precipitate was collected by suction filtration and washed well with 1M HCl and water. After drying in vacuo 3-(4-chlorophenyl)-4-(5-phenyl-2-benzimidazolyl)butanoic acid•HCl (0.36 g) was obtained as beige coloured solid.

Provenance & Evidence