Acetic Acid → HCID 45381086, compound

Participants

Reaction Steps

The solution of 7,8-dichloro-3-phenyl-3,4-dihydropyrido[1,2-a]benzimidazol-1(2H)-one (96 mg) in a mixture of acetic acid (2 ml) and conc. HCl (1 ml) was heated to reflux shortly and then stirred at rt for 1 h. All volatiles were removed at the water aspirator at elevated temperature and the residue was dried by azeotropic distillation with toluene. The crude was triturated with chloroform (5 ml) to give 4-(5,6-dichloro-2-benzimidazolyl)-3-phenylbutanoic acid•HCl (102 mg) as colourless solid.

Provenance & Evidence