Ammonia → HCID 66758968, compound

Participants

Reaction Steps

A 1:1-mixture of 7-chloro-3-phenyl-3,4-dihydropyrido[1,2-a]-benzimidazol-1(2H)-one and 8-chloro-3-phenyl-3,4-dihydropyrido[1,2-a]benzimidazol-1(2H)-one (222 mg)—see example 1.27.1—was dissolved in 1,4-dioxane (3 ml) at reflux temperature. A 25% solution of ammonia in water (2 ml) was added to give a light red solution. Refluxing was continued for 1 h. All volatiles were removed at the water aspirator to leave a light red oil, which was dissolved in acetone (3 ml). Soon precipitation occurs and the solid is isolated by suction filtration and washed with acetone. After drying in vacuo 4-(5-chloro-2-benzimidazolyl)-3-(4-chlorophenyl)-butyramide (120 mg) is obtained as colourless solid.

Provenance & Evidence