Dichloromethane → HCID 45381311, compound

Participants

Reaction Steps

To a solution of 4-iodo-1,2-phenylenediamine (0.47 g) in dichloromethane (3 ml) the solution of 3-(2-methylphenyl)glutaric anhydride (0.41 g) in dichloromethane (4 ml) was added with stirring at rt. Almost instantaneously an resinous precipitate is formed. After 1 h at rt all volatiles are removed in vacuo and the residue is taken up in 1,4-dioxane (2 ml). 4M HCl in 1,4-dioxane (3 ml) is added and the resulting dark solution is heated to reflux for 1 h. Again all volatiles are removed at the water aspirator and the residue is recrystallised from EtOAc/methanol to give 4-(5-iodo-2-benzimidazolyl)-3-(2-methylphenyl)butanoic acid•HCl (0.49 g) as light brown solid.

Provenance & Evidence