4-Iodobenzene-1,2-diamine → HCID 45381313, compound

Participants

Reaction Steps

To a solution of 4-iodo-1,2-phenylenediamine (0.47 g) in dichloromethane (2 ml) the solution of 3-(4-chloro-2-methylphenyl)glutaric anhydride (0.48 g) in dichloromethane (2 ml) was added with stirring at rt. Almost instantaneously an resinous precipitate is formed. After 1 h the mixture was cooled in an ice bath and the solvent was removed by decantation. The residue is dissolved in acetic acid (3 ml). Conc. HCl (1 ml) is added and the resulting solution is heated to reflux for 1 h. All volatiles are removed at the water aspirator and the residue is triturated with acetic acid and acetone to leave 3-(4-chloro-2-methylphenyl)-4-(5-iodo-2-benzimidazolyl)butanoic acid HCl (0.62 g) as light brown solid.

Provenance & Evidence