反应详情

To the suspension of ethyl N-(4-chlorophenyl)-glycinate (10.4 g) in ethanol (4 ml) the solution of NaOH (4 g) in water (40 ml) was added. Upon heating a clear solution is formed, which is refuxed for 0.5 h. The solution is decolorized with activated carbon and filtered while hot. The filtrate is cooled in an ice bath and conc. HCl (5 ml) is added dropwise with stirring (pH 1-2). The precipitate formed is collected by suction filtration and washed with water. After drying in vacuo N-(4-chlorophenyl)-glycine (6.51 g) is obtained as colourless crystals.

1. additionwas added
2. temperatureUpon heating a clear solution
3. customis formed
4. filtrationfiltered while hot
5. temperatureThe filtrate is cooled in an ice bath
6. additionconc. HCl (5 ml) is added dropwise
7. customThe precipitate formed
8. filtrationis collected by suction filtration
9. washwashed with water
10. dry with materialAfter drying in vacuo N-(4-chlorophenyl)-glycine (6.51 g)
11. customis obtained as colourless crystals