Formamide → 4-Chloro-phthalimide

HRID 1402842Notes

Reaction equation

HRID 1402842 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=O)[O:8][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1.C([NH2:15])=O>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:8])[NH:15][C:6](=[O:7])[C:5]2=[CH:11][CH:12]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 670444-Chlorophthalic anhydride

Product 1

HCID 2312394-Chloro-phthalimide

Conditions

Temperature
150 °C

Procedure

The suspension of 4-chlorophthalic anhydride (3 g) in formamide (15 ml) was heated with stirring to 150° C. for 1 h. The resulting yellowish solution was cooled to rt and the product was fractionally precipitated by addition of water to yield 4-chlorophthalimide (1.91 g) as colourless crystals.

Workup

  1. temperaturewas heated
  2. temperatureThe resulting yellowish solution was cooled to rt
  3. customthe product was fractionally precipitated by addition of water

Sources & evidence

ORD record
ord-a4d8cdbd42d94e47b4b7adb10aff1b6f
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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