Lithium hydroxide, monohydrate → HCID 66759593, compound

Participants

Reaction Steps

With stirring at rt the solution of lithium hydroxide monohydrate (0.29 g) in water (1.5 ml) was added to the solution of ethyl 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoate (0.64 g) in methanol (10 ml). The cloudy solution was stirred at rt for 2 h. Then the methanol was removed by distillation and the residue was diluted with water (3 ml). With ice-cooling conc. HCl (1 ml) was added dropwise to the stirred solution. The precipitate formed is kept at 0° C. for 0.5 h and collected by suction filtration. After washings with 1M HCl and water the solid is dried in vacuo to provide 4-(5-chloro-2-isoindolinyl)-3-(4-chlorophenyl)-4-oxobutanoic acid (0.56 g) as colourless solid.

Provenance & Evidence