3-(4-Chlorophenyl)-1-(2-fluorophenyl)propan-1-one → HCID 131732157, compound

HRID 1402880Notes

Reaction equation

HRID 1402880 reaction equation
ClC1C=CC(CCC(C2C=CC=CC=2F)=O)=CC=1.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[CH:29]/[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][CH:21]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][C:36]=2[F:41])=[CH:29]\[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 247260933-(4-Chlorophenyl)-1-(2-fluorophenyl)propan-1-oneHCID 131732158HCID 131732158, compound

Product 1

HCID 131732157HCID 131732157, compound

Procedure

By a procedure similar to that of example 1.85.3, starting from 3-(4-chlorophenyl)-1-(2-fluorophenyl)propan-1-one, (Z)-ethyl 5-(4-chlorophenyl)-3-(2-fluorophenyl)pent-2-enoate and (E)-ethyl 5-(4-chlorophenyl)-3-(2-fluorophenyl)pent-2-enoate were obtained as colourless oils.

Sources & evidence

ORD record
ord-89a65f5a302b4897b143679febbc7217
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

Loading…