Acetophenone → 3-Chlorochalcone

HRID 1402884Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)(=[O:12])[CH3:11]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1

Participants

Reactant 2

HCID 7410Acetophenone

HCID 114773-Chlorobenzaldehyde

Product 1

HCID 953263-Chlorochalcone

Procedure

By a procedure similar to that of example 1.59.1, starting from 3-chlorobenzaldehyde and acetophenone, 3-(3-chlorophenyl)-1-phenylprop-2-en-1-one was obtained as yellowish solid.

Sources & evidence

ORD record: ord-c6e3f57527b047cf8333f438a29ebab1
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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