HCID 66759561, compound → (e)-Ethyl 5-(4-chloro-3-fluorophenyl)-3-phenylpent-2-enoate

HRID 1402899Notes

Reaction equation

HRID 1402899 reaction equation
ClC1C=CC(CCC(C2C=CC=CC=2)=O)=CC=1F.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[CH:29]/[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][C:21]=1[F:41]>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[CH:29]\[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[CH:22][C:21]=1[F:41]

Participants

3

Reactant 2

HCID 66759561HCID 66759561, compoundHCID 131732164HCID 131732164, compound

Product 1

HCID 131732163(e)-Ethyl 5-(4-chloro-3-fluorophenyl)-3-phenylpent-2-enoate

Procedure

By a procedure similar to that of example 1.85.3, starting from 3-(4-chloro-3-fluorophenyl)-1-phenylpropan-1-one, (Z)-ethyl 5-(4-chloro-3-fluorophenyl)-3-phenylpent-2-enoate and (E)-ethyl 5-(4-chloro-3-fluorophenyl)-3-phenylpent-2-enoate were obtained as colourless oils.

Sources & evidence

ORD record
ord-f9557753fa564c17ae4ca38250cbf6ef
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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