HCID 43438809, compound → HCID 44220698, compound

HRID 1402903Notes

Reaction equation

HRID 1402903 reaction equation
BrC1C=CC(CCC(C2C=CC=CC=2)=O)=C(F)C=1.[Br:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[CH:29]/[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[C:22]([F:41])[CH:21]=1>>[Br:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][CH2:27]/[C:28](/[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)=[CH:29]\[C:30]([O:32][CH2:33][CH3:34])=[O:31])=[C:22]([F:41])[CH:21]=1

Participants

3

Reactant 2

HCID 43438809HCID 43438809, compoundHCID 44222816HCID 44222816, compound

Product 1

HCID 44220698HCID 44220698, compound

Procedure

By a procedure similar to that of example 1.85.3, starting from 3-(4-bromo-2-fluorophenyl)-1-phenylpropan-1-one, (Z)-ethyl 5-(4-bromo-2-fluorophenyl)-3-phenylpent-2-enoate and (E)-ethyl 5-(4-bromo-2-fluorophenyl)-3-phenylpent-2-enoate were obtained as colourless oils.

Sources & evidence

ORD record
ord-6d0aee530b3e4addaafdb2448b7473b3
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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