2-(3-Indolyl)ethylphenyl ketone → HCID 44222629, compound

HRID 1402913Notes

Reaction equation

HRID 1402913 reaction equation
N1C2C(=CC=CC=2)C(CCC(C2C=CC=CC=2)=O)=C1.[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:22]([CH2:29][CH2:30]/[C:31](/[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[CH:32]/[C:33]([O:35][CH2:36][CH3:37])=[O:34])=[CH:21]1>>[NH:20]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[C:22]([CH2:29][CH2:30]/[C:31](/[C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)=[CH:32]\[C:33]([O:35][CH2:36][CH3:37])=[O:34])=[CH:21]1

Participants

3

Reactant 2

HCID 1934852-(3-Indolyl)ethylphenyl ketoneHCID 44220900HCID 44220900, compound

Product 1

HCID 44222629HCID 44222629, compound

Procedure

By a procedure similar to that of example 1.85.3, starting from 3-(1H-indol-3-yl)-1-phenylpropan-1-one, (Z)-ethyl 5-(1H-indol-3-yl)-3-phenylpent-2-enoate and (E)-ethyl 5-(1H-indol-3-yl)-3-phenylpent-2-enoate were obtained as light tan oils.

Sources & evidence

ORD record
ord-04feed9d814241679fe0565aceb84c03
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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