Hydrochloric Acid → HCID 12646051, compound

Participants

Reaction Steps

A mixture of aniline (1.4 ml), ethyl acrylate (3.4 ml), and conc. HCl (1.6 ml) in ethanol (17 ml) was heated to reflux for 24 h. Then the solvent was removed and the residue partitioned between an excess of ammonia solution and dichloromethane. The organic layer was separated, washed with brine, dried (MgSO4), and evaporated. The residue was purified by flash chromatography on silica gel (hexane/ethyl acetate 2:1) to provide ethyl N-(4-chlorophenyl)-3-aminopropionate (1.27 g) as yellowish oil.

Provenance & Evidence