Dichloromethane → HCID 178423945, compound

Participants

Reaction Steps

3-Methyl-1,2-phenylenediamine (61 mg) and 3-(2-naphthyl)glutaric anhydride (120 mg) were dissolved in dichloromethane (2 ml) with heating. The solution was stirred at rt for 1 h. The solvent was removed and the residue was dissolved in 1,4-dioxane (1 ml) with heating. 4M HCl in 1,4-dioxane (1 ml) was added and the solution was heated to reflux for 1 h. The precipitate formed was isolated by suction filtration, washed with 1,4-dioxane, and dried to give 4-(4-methyl-2-benzimidazolyl)-3-(2-naphthyl)butanoic acid HCl (162 mg) as beige coloured solid.

Provenance & Evidence