4-Chloro-1,2-diaminobenzene → HCID 45381981, compound

Participants

Reaction Steps

4-Chloro-1,2-phenylenediamine (285 mg) and 2-(4-chlorophenyl)maleic anhydride (420 mg) were dissolved in dichloromethane (4 ml) with heating. The dark solution was stirred at rt for 1 h. The solvent was removed in vacuo and the residue was dissolved in 1M HCl in acetic acid (4 ml). The solution was heated to reflux for 1 h, treated with charcoal, and filtered. From the filtrate the solvent was removed and the residue crystallised from acetone/ethyl acetate to give 3-(5-chloro-2-benzimidazolyl)-2-(4-chlorophenyl)propanoic acid HCl (130 mg) as light orange solid.

Provenance & Evidence