2-Amino-4-(trifluoromethyl)benzenethiol → HCID 66760053, compound

HRID 1402941Notes

Reaction equation

HRID 1402941 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[SH:12].[Cl:13][C:14]1[CH:19]=[CH:18][C:17]([CH:20]2[CH2:26][C:25](=O)[O:24][C:22](=[O:23])[CH2:21]2)=[CH:16][CH:15]=1>>[F:11][C:8]([F:9])([F:10])[C:6]1[CH:5]=[CH:4][C:3]2[S:12][C:25]([CH2:26][CH:20]([C:17]3[CH:16]=[CH:15][C:14]([Cl:13])=[CH:19][CH:18]=3)[CH2:21][C:22]([OH:24])=[O:23])=[N:1][C:2]=2[CH:7]=1

Participants

3

Reactant 2

HCID 880422-Amino-4-(trifluoromethyl)benzenethiolHCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Product 1

HCID 66760053HCID 66760053, compound

Procedure

By a procedure similar to that of example 1.55, starting from 2-amino-4-trifluoromethylthiophenol and 3-(4-chlorophenyl)glutaric anhydride, 4-(5-trifluoromethyl-2-benzothiazolyl)-3-(4-chlorophenyl)butanoic acid was obtained as colourless solid.

Sources & evidence

ORD record
ord-f54632c980464557817b75e3d8b43d1e
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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