2-Amino-5-chlorobenzamide → HCID 178525386, compound

HRID 1402943Notes

Reaction equation

HRID 1402943 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:14][C:13](=[O:15])[O:12][C:10](=O)[CH2:9]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:25]=[C:21]([C:22]([NH2:24])=[O:23])[C:20]([NH2:26])=[CH:19][CH:18]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH2:9][C:10]2[N:24]=[C:22]([OH:23])[C:21]3[C:20](=[CH:19][CH:18]=[C:17]([Cl:16])[CH:25]=3)[N:26]=2)[CH2:14][C:13]([OH:12])=[O:15])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 788762-Amino-5-chlorobenzamideHCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Product 1

HCID 178525386HCID 178525386, compound

Procedure

By a procedure similar to that of 1.133, starting from 3-(4-chlorophenyl)glutaric anhydride and 5-chloroanthranilamide, 3-(4-chlorophenyl)-4-(6-chloro-4-hydroxy-2-quinazolinyl)butanoic acid was obtained as colourless solid.

Sources & evidence

ORD record
ord-c997a29e11f44ed48024a4b53e21e8cf
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

Loading…