Dimethyl malonate → HCID 66760242, compound

HRID 1402945Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:18])[CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[C:19]([O:26][CH3:27])(=[O:25])[CH2:20][C:21]([O:23][CH3:24])=[O:22]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:18])[CH2:9][CH:10]([CH:20]([C:19]([O:26][CH3:27])=[O:25])[C:21]([O:23][CH3:24])=[O:22])[C:11]2[CH:12]=[CH:13][C:14]([Cl:17])=[CH:15][CH:16]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7943Dimethyl malonate

HCID 227894′-Bromo-4-chlorochalcone

Product 1

HCID 66760242HCID 66760242, compound

Procedure

By a procedure similar to that of example 1.59.2, starting from 1-(4-bromophenyl)-3-(4-chlorophenyl)prop-2-en-1-one and dimethyl malonate, dimethyl 2-(3-(4-bromophenyl)-1-(4-chlorophenyl)-3-oxopropyl)malonate was obtained as colourless solid.

Sources & evidence

ORD record: ord-b9963d4d37f4472a9785f19afcb5ad35
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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