Dimethyl malonate → HCID 66759919, compound

HRID 1402950Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1.[C:22]([O:29][CH3:30])(=[O:28])[CH2:23][C:24]([O:26][CH3:27])=[O:25]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:23]([C:22]([O:29][CH3:30])=[O:28])[C:24]([O:26][CH3:27])=[O:25])[CH2:9][C:10](=[O:11])[C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7943Dimethyl malonate

HCID 54366908HCID 54366908, compound

Product 1

HCID 66759919HCID 66759919, compound

Procedure

By a procedure similar to that of example 1.59.2, starting from 3-(4-chlorophenyl)-1-(4-(trifluoromethyl)-phenyl)prop-2-en-1-one and dimethyl malonate, dimethyl 2-(1-(4-chlorophenyl)-3-oxo-3-(4-(trifluoromethyl)phenyl)-propyl)malonate was obtained as colourless solid.

Sources & evidence

ORD record: ord-afe38aa818a6426b82b0d932c1718223
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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