2-Acetylnaphthalene → 4-Phenoxychalcone

HRID 1402968Notes

Reaction equation

HRID 1402968 reaction equation
[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16]1[C:25]2[C:20](=CC=CC=2)[CH:19]=[CH:18][C:17]=1[C:26](=[O:28])[CH3:27]>>[O:1]([C:8]1[CH:15]=[CH:14][C:11]([CH:12]=[CH:27][C:26]([C:17]2[CH:18]=[CH:19][CH:20]=[CH:25][CH:16]=2)=[O:28])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 71222-AcetylnaphthaleneHCID 661394-Phenoxybenzaldehyde

Product 1

HCID 1518684-Phenoxychalcone

Procedure

Synthesised according to example 1.59.1 using 4-phenoxybenzaldehyde (3.0 g, 15.1 mmol) and 1-(naphthalen-2-yl)ethanone (2.58 g, 15.1 mmol); pale yellow solid; yield: 4.70 g (89%);

Workup

  1. customSynthesised

Sources & evidence

ORD record
ord-9a55928037a84bedb1772e2d7661c0ff
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

Loading…