HRID1403015

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2733380

2-Fluoro-5-(trifluoromethyl)phenyl isocyanate

C8H3F4NO

结构：CN1CCN(c2cnc3c(Oc4ccc(N)c(F)c4)ccnc3n2)CC1

HCID46901761

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(c2cnc3c(Oc4ccc(NC(=O)Nc5cc(C(F)(F)F)ccc5F)c(F)c4)ccnc3n2)CC1

HCID44133016

未命名化合物

PROCEDURE

实验过程

Method F3 was used with 2-Fluoro-5-(trifluoromethyl)phenyl isocyanate and 2-fluoro-4-(3-(4-methylpiperazin-1-yl)pyrido[3,2-b]pyrazin-8-yloxy)aniline to give the title compound as a yellow solid. Yield: 30 mg (64%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3bdc01a3182447cbbe4abfa5f8cbb23e
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08912191B2
来源说明: uspto-grants-2014_12

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[N:12]=[C:13]=[O:14].[F:15][C:16]1[CH:22]=[C:21]([O:23][C:24]2[C:29]3=[N:30][CH:31]=[C:32]([N:34]4[CH2:39][CH2:38][N:37]([CH3:40])[CH2:36][CH2:35]4)[N:33]=[C:28]3[N:27]=[CH:26][CH:25]=2)[CH:20]=[CH:19][C:17]=1[NH2:18]>>[F:15][C:16]1[CH:22]=[C:21]([O:23][C:24]2[C:29]3=[N:30][CH:31]=[C:32]([N:34]4[CH2:35][CH2:36][N:37]([CH3:40])[CH2:38][CH2:39]4)[N:33]=[C:28]3[N:27]=[CH:26][CH:25]=2)[CH:20]=[CH:19][C:17]=1[NH:18][C:13]([NH:12][C:3]1[CH:4]=[C:5]([C:8]([F:11])([F:10])[F:9])[CH:6]=[CH:7][C:2]=1[F:1])=[O:14]