HRID1403016

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11096760

未命名化合物

结构：CN1CCN(c2cnc3c(Oc4ccc(N)c(F)c4)ccnc3n2)CC1

HCID46901761

未命名化合物

PRODUCTS

生成物

结构：CN1CCN(c2cnc3c(Oc4ccc(NC(=O)Nc5cc(C(C)(C)C)nn5-c5ccccc5)c(F)c4)ccnc3n2)CC1

HCID44133361

未命名化合物

PROCEDURE

实验过程

Method F3 was used with 3-tert-butyl-5-isocyanato-1-phenyl-1H-pyrazole and 2-fluoro-4-(3-(4-methylpiperazin-1-yl)pyrido[3,2-b]pyrazin-8-yloxy)aniline to give the title compound as a cream-colored solid. Yield: 44 mg (77%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0d93e51399b7487f8f19635c27fba5e0
来源数据集: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08912191B2
来源说明: uspto-grants-2014_12

反应 SMILES

[C:1]([C:5]1[CH:9]=[C:8]([N:10]=[C:11]=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:26]=[C:25]([O:27][C:28]2[C:33]3=[N:34][CH:35]=[C:36]([N:38]4[CH2:43][CH2:42][N:41]([CH3:44])[CH2:40][CH2:39]4)[N:37]=[C:32]3[N:31]=[CH:30][CH:29]=2)[CH:24]=[CH:23][C:21]=1[NH2:22]>>[C:1]([C:5]1[CH:9]=[C:8]([NH:10][C:11]([NH:22][C:21]2[CH:23]=[CH:24][C:25]([O:27][C:28]3[C:33]4[C:32](=[N:37][C:36]([N:38]5[CH2:39][CH2:40][N:41]([CH3:44])[CH2:42][CH2:43]5)=[CH:35][N:34]=4)[N:31]=[CH:30][CH:29]=3)=[CH:26][C:20]=2[F:19])=[O:12])[N:7]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:6]=1)([CH3:4])([CH3:2])[CH3:3]