2-Fluoro-5-(trifluoromethyl)phenyl isocyanate → HCID 44133910, compound

HRID 1403028Notes

Reaction equation

HRID 1403028 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][CH:19]=1)[O:5][C:6]1[C:15]2[NH:14][C:13](=[O:16])[CH:12]=[N:11][C:10]=2[N:9]=[CH:8][CH:7]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1[N:31]=[C:32]=[O:33]>>[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1[NH:31][C:32]([NH:1][C:2]1[CH:19]=[CH:18][CH:17]=[C:4]([O:5][C:6]2[C:15]3[NH:14][C:13](=[O:16])[CH:12]=[N:11][C:10]=3[N:9]=[CH:8][CH:7]=2)[CH:3]=1)=[O:33]

Participants

3

Reactant 2

HCID 27333802-Fluoro-5-(trifluoromethyl)phenyl isocyanateHCID 468999468-(3-aminophenoxy)pyrido[2,3-b]pyrazin-2(1H)-one

Product 1

HCID 44133910HCID 44133910, compoundYield 73%

Procedure

Method F2 was used with 8-(3-aminophenoxy)pyrido[2,3-b]pyrazin-2(1H)-one and 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene to afford the title compound as a white solid (49 mg, 73%).

Sources & evidence

ORD record
ord-c69dd083cf6247549c3ba6015a415993
Source dataset
uspto-grants-2014_12
Patent number
US08912191B2

Reaction notes

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