Acetic Acid → HCID 86701139, compound

Participants

Reaction Steps

A solution of paraformaldehyde (0.122 g), 2-(methylamino)ethanol (0.330 g), and acetic acid (0.13 ml) in ethanol (4 ml) was stirred at 80° C. for 2 hours. After cooling, a solution of compound (6) (0.200 g) in methylene chloride (4 ml) was added to the reaction solution, and the mixture was stirred overnight at room temperature. The reaction solution was partitioned between chloroform and water. The organic layer was neutralized with an aqueous sodium bicarbonate solution, then washed with brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off, and the residue was then purified by neutral silica gel column chromatography (chloroform/methanol) to obtain compound (37) (0.130 g, 56%) as a pale yellow solid.

Provenance & Evidence