Quinoline-3-boronic acid → 2-(4-Hydroxycyclohexylamino)-4-(1-(quinolin-3-yl)isoquinolin-5-yl)benzamide

Participants

Reaction Steps

3-(5-Bromoisoquinolin-1-yl)quinoline was obtained according to Example 2(1) using 3-quinolineboronic acid instead of 4-cyano-3-(4-hydroxycyclohexylamino)phenylboronic acid pinacol ester. A compound of Comparative Example 1 was obtained as a pale yellow solid (yield based on 3 steps: 24%) according to Example 2(3) using the obtained 3-(5-bromoisoquinolin-1-yl)quinoline instead of compound (2b) and 4-cyano-3-(4-hydroxycyclohexylamino)phenylboronic acid pinacol ester instead of 4-cyano-3-(ethylamino)phenylboronic acid pinacol ester.

Provenance & Evidence